Inhibitors list

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[<>] Name [<>] Alias [<>] Molecular weight [<>] Solubility [<>] Chem Name [<>] Formula [<>] Structure [<>] Inhibits
Adaphostin NSC 680410
BCR-ABL tyrosine kinase inhibitor
393.5393.5 DMSO
Ethanol
4-Amino-N-(2,5- dihydroxybenzyl)adamantyl Benzoate, 4-(2,5-Dihydroxy-benzylamino) benzoic Acid Adamantan-1-yl Ester C24H27NO4 Adaphostin big.jpg BCR-ABL
Akt1/2 kinase inhibitor 551.64551.64 DMSO 1,3-Dihydro-1-(1-((4- (6-phenyl-1H-imidazo[4,5-g] quinoxalin-7-yl)phenyl) methyl)-4-piperidinyl)-2H- benzimidazol-2-one trifluoroa- cetate salt hydrate C34H29N7O · xC2HF3O2 · yH2O Akt inhibitor big.jpg AKT1
Dasatinib Abelson-kinase Inhibitor 488.1488.1 DMSO N-(2-chloro-6-methylphenyl)-2- [[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2- methyl-4-pyrimidinyl]amino]-5- thiazolecarboxamide monohydrate C22H26ClN7O2S Dasatinib.gif BCR-ABL
GW2974 EGFR and Her2 Inhibitor 395.46395.46 DMSO N4-(1-Benzyl-1H- indazol-5-yl)-N6,N6- dimethyl-pyrido­[3,4-d] ­pyrimidine-4,6-diamine C23H21N7 GW2974.jpg ERBB2
GW583340 GW583340 di HCl
EGFR and Her2 Inhibitor
671.03671.03 DMSO 4-[3-Chloro-4-[(3-fluorophenyl)methoxy] phenylamino]-6-[2-[[2-(methylsulfonyl) ethyl]aminomethyl]-4- thiazolyl]quinazoline dihydrochloride C28H25ClFN5O3S2·2HCl GW583340.jpg ERBB2
Gleevec Imatinib Mesylate 589.7589.7 DMSO 4-[(4-methylpiperazin-1-yl) methyl]-N- [4-methyl-3- [(4-pyridin-3- ylpyrimidin-2-yl) amino]-phenyl]-benzamide C29H31N7O.CH3SO3H Imatinib mesylate.jpg BCR-ABL
KIT
PDGFRA
PDGFRB
KRN633 VEGF Receptor Tyrosine Kinase Inhibitor III 416.9416.9 DMSO N-(2-Chloro-4-((6,7- dimethoxy-4-quinazolinyl)oxy) phenyl)-N′-propylurea C20H21ClN4O4 Krn633.jpg VEGFR1
VEGFR2
VEGFR3
LY294002 343.8343.8 DMSO
Ethanol
2-(4-Morpholinyl)-8- phenyl-4H-1- benzopyran-4-one hydrochloride C19H17NO3 Ly294002 big.jpg PIK3CA
Lapatinib GW572016
GW-2016
Tykerb
925.48925.48 DMSO N-[3-chloro-4-[(3-fluorophenyl) methoxy]phenyl]-6-[5- [(2-methylsulfonylethylamino)methyl]-2- furyl]quinazolin-4-amine C29H26ClFN4O4S . 2C7H8O3S Lapatinib.jpg ERBB2
MAZ51 Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor 314.1314.1 DMSO 3-(4-Dimethylamino-naphthalen-1- ylmethylene)-1,3- dihydro-indol-2-one C21H18N2O Maz51.gif VEGFR1
VEGFR2
VEGFR3
PD180970 Src kinase inhibitor
PD 180970
429.28429.28 DMSO 6-(2,6-Dichloro-phenyl)-2- (4-fluoro-3-methyl-phenylamino)-8- methyl-8H-pyrido[2,3-d] pyrimidin-7-one C21H15Cl2FN4O Pd180790.gif BCR-ABL
PD184352 478.67478.67 DMSO 2-(2-Chloro-4-iodo- phenylamino)-N- cyclopropylmethoxy-3,4- difluoro-benzamide C17H14ClF2IN2O2 Pd184352.gif MEK1
PD 98059 267.28267.28 DMSO
Methanol
2'-Amino-3'-methoxyflavone C16H13NO3 Pd98059.gif ERK
PP1 281.4281.4 DMSO 4-Amino-5-(4-methylphenyl)-7- (t-butyl)pyrazolo[3,4-d]pyrimidine C16H19N5 Pp1 big.jpg FYN
PP2 301.8301.8 DMSO 4-amino-5-(4-chlorophenyl)-7- (t-butyl)pyrazolo[3,4,d]pyrimidine C15H16ClN5 Pp2 big.jpg FYN
Rapamycin 914.2914.2 DSMO
Methanol
23,27-Epoxy-3H- pyrido[2,1-c] [1,4]oxaazacyclohentriacontine C51H79NO13 Rapamycin.jpg MTOR
SB-590885 00 ? ? SB-590885.jpg BRAF
SL 327 MEK1/2 Inhibitor 335.35335.35 DMSO Z-& E-a-(Amino-((4-aminophenyl)thio) methylene)-2-(trifluoromethyl) benzeneacetonitrile C16H12F3N3S Sl327.gif MEK1
SU11274 SU 11274 568.1568.1 DMSO (3Z)-N-(3-Chlorophenyl)-3- ((3,5-dimethyl-4-((4-methylpiperazin-1-yl) carbonyl)-1H-pyrrol-2-yl) methylene)-N-methyl-2-oxo- 2,3-dihydro-1H-indole-5-sulfonamide C28H30ClN5O4S SU11274.jpg MET
SU 011248 Sunitinib-L-malate 532.56532.56 DMSO
Methanol
Water
(Z)-N-[2-(Diethylamino)ethyl]-5- (5-fluoro-2-oxo-2,3-dihydro-1H- indol-3-ylidenemethyl)-2,4- dimethyl-1H -pyrrole-3-carboxamide 2(S)-hydroxybutanedioic acid (1:1) C22H27FN4O2 . C4H6O5 Su011248.gif VEGFR2
SU 4312 264.3264.3 DMSO 3-[[4-(dimethylamino)phenyl] methylene]-1,3-dihydro- 2H-indol-2-one C17H16N2O Su4312.jpg VEGFR1
VEGFR2
VEGFR3
SU 5416 238.28238.28 ? 1,3-Dihydro-3-[(3,5-dimethyl- 1H-pyrrol-2-yl)methylene]- 2H-indol-2-one C15H14N2O Su5416.gif VEGFR1
VEGFR2
VEGFR3
SU 6656 Src family kinase inhibitor
SU6656
371.45371.45 DMSO 2,3-Dihydro-N,N-dimethyl-2- oxo-3-[(4,5,6,7-tetrahydro-1H- indol-2-yl)methylene]-1H- indole-5-sulfonamide C19H21N3O3S Su6656 big.jpg FYN
Sorafenib Tosylate 637.04637.04 DMSO p-Toluenesulfonate Salt C21H16ClF3N4O3 . C7H8O3S Sorafenib.jpg VEGFR2
VEGFR3
Suns No. 48 VEGFR-2 inhibitor 310.4310.4 DMSO
Ethanol
(Z)-3-[(2,4-Dimethyl-3- (ethoxycarbonyl)pyrrol-5-yl) methylidenyl]indolin-2-one C18H18N2O3 Sunsno48.gif VEGFR2
Sutent SU-11248
Sunitinib Maleate
532.57532.57 DMSO N-[2-(diethylamino)ethyl]-5- [(Z)-(5-fluoro-1,2-dihydro-2- oxo-3H-indol-3-ylidine) methyl]-2,4-dimethyl-1H- pyrrole-3-carboxamide C22H27FN4O2 . C4H6O5 Sunitinib.jpg KIT
Tyrphostin AG957 AG957
NSC 654705
273.3273.3 DMSO 4-Amino-N-(2,5-dihydroxybenzyl) methyl benzoate C15H15NO4 Tyrphostin ag 957 big.jpg BCR-ABL
U0126 380.5380.5 DMSO 1,4-Diamino-2,3- dicyano-1,4-bis (2-aminophenylthio)-butadiene C18H16N6S2 U0126.jpg MEK1
Vatalanib PTK 787 346.82346.82 DMSO 1-(4-Choroanilino)-4- (4-pyridylmethyl)phtalazine C20H15ClN4 Vatalin.gif VEGFR2
ZM 447439 567.71567.71 DMSO
Acetic acidl
Toluene
N-[4-[[6-Methoxy-7- [3-(4-morpholinyl)propoxy]-4- quinazolinyl]amino] phenyl]benzamide C29H31N5O4x3H20 Zm447439 big.jpg AURKA
AURKB